Pedplot

Sermorelin plotter

Half-life estimate, not bloodwork or dosing advice. Disclaimer.

t½ 14mTmax 29m100% parentestimate

The prefilled numbers are an example input to draw the curve, not a dose; Pedplot does not suggest one. To step a dose up, add another row of the same compound with a later start day.

Peaks, troughs, and half-life
Not a blood level. The chart shows the estimated milligrams of the drug still in the body, so it will not match a lab result in ng/dL. How the model works. Washout continues after the last dose. Mixed IU and mg protocols are not summed.

Sermorelin

Peak

0.200 mg

Trough

0.000 mg

Swing

100%

~Steady state

1d

~Washout

6h

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GHRH analog with a very short plasma half-life. Daily pulses, almost no multi-day build-up. There is no ester, so the line is the dose itself. The half-life is an estimate. Methodology.

Half-life14m
Time to peak29m
Parent hormone100%
Example input0.2 mg
Example frequencyevery day
Example length8 weeks
Data qualityLow

GHRH(1-29) disappears with a 4.3 min half-life during IV infusion (Soule et al. 1994); a review gives 10–20 min after SC injection (Sinha et al. 2020). Modeled as 0.01 d, about 14 min; Tmax is an estimate. How the model works.

The example curve

0.2 mg every day for 8 weeks. With a 14m half-life, it levels off around day 1. The row runs longer than that, so the plateau is on the chart. Between doses it runs from about 0 to 0.2 mg, a swing of 100%. Each dose is its own spike. After the last dose, the tail takes about 0.3 days to fall to a few percent.

CJC-12950.3 days longer (7h vs 14m).

Sources

  1. Paper. Soule et al. 1994, J Clin Endocrinol Metab (abstract): GHRH-(1-29)-NH2 disappearance half-time 4.3 min during IV infusion
  2. Paper. Sinha et al. 2020, Transl Androl Urol, Table 1 (review): sermorelin SC half-life 10–20 min
  3. Community estimate. Tmax estimate; no human figure found