Pedplot

Test U plotter

Half-life estimate, not bloodwork or dosing advice. Disclaimer.

t½ 34dTmax 7d63% parent

The prefilled numbers are an example input to draw the curve, not a dose; Pedplot does not suggest one. To step a dose up, add another row of the same compound with a later start day.

Peaks, troughs, and half-life
Not a blood level. The chart shows the estimated milligrams of the drug still in the body, so it will not match a lab result in ng/dL. How the model works. Washout continues after the last dose. Mixed IU and mg protocols are not summed.

Testosterone undecanoate

Peak

613 mg

Trough

162 mg

Swing

74%

~Steady state

210d

~Washout

179.3d

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Long ester. Slow rise, heavy accumulation, and a long washout — useful for seeing how a long half-life changes the curve. A 750 mg dose is about 473 mg of testosterone, and that is what the line draws. Also called Testosterone undecanoate, Aveed.

Half-life34d
Time to peak7d
Parent hormone63%
Example input750 mg
Example frequencyevery 70 days
Example length30 weeks
Data qualityMedium

Half-life 34 d for castor-oil TU (Behre et al. 1999: 33.9 d); Tmax 7 d (Aveed label, Nebido SmPC); 63% testosterone (Nebido SmPC: 1000 mg = 631.5 mg). Nebido's 90-day figure is a release-rate constant and is not used. How the model works.

The example curve

750 mg every 70 days for 30 weeks. With a 34d half-life, it levels off around day 210. The row ends before that, so the line is still climbing when it stops. Between doses it runs from about 162 to 613 mg, a swing of 74%. Each dose is its own spike. After the last dose, the tail takes about 179.3 days to fall to a few percent.

Sources

  1. Paper. Behre et al. 1999, Eur J Endocrinol (abstract): castor-oil preparation half-life 33.9 ± 4.9 days
  2. FDA label. Aveed FDA label, 12.3 Pharmacokinetics: peak after a median of 7 days (range 4 to 42) after 750 mg IM
  3. SmPC. Nebido 1000 mg/4 ml UK SmPC, sections 2 and 5.2: 1000 mg corresponds to 631.5 mg testosterone; Cmax after 7 days
  4. Computed (PubChem). PubChem molecular weights, testosterone undecanoate: 288.4 ÷ 456.7 = 0.63