Pedplot

Trulicity plotter

Half-life estimate, not bloodwork or dosing advice. Disclaimer.

t½ 5dTmax 2d100% parent

To step a dose up, add another row of the same compound with a later start day. The chart is remaining active amount, not serum concentration.

Peaks, troughs, and half-life
Estimated remaining active mg. Washout continues after the last dose. Mixed IU and mg protocols are not summed.

Dulaglutide

Peak

1.21 mg

Trough

0.603 mg

Swing

50%

~Steady state

25d

~Washout

27d

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How to read this chart

Trulicity. Weekly GLP-1 with a ~5 day half-life, similar ballpark to tirzepatide.

The default row models 0.750 mg as a subcutaneous dose, weekly, for 8 weeks.

Also called Dulaglutide.

The numbers

Half-life5d
Time to peak2d
Parent hormone100%
Default dose0.750 mg
Default frequencyWeekly
Default duration8 weeks

What the default curve does

On that default row the model counts 8 doses. Steady state is about day 25. Washout runs to about day 27. In the last interval the peak is 1.21 mg and the trough is 0.603 mg, a swing of 50%.

How often a dose is still there

A half-life of 5d means a dose is still present at the next one, so the line climbs and then levels off.

Closest comparison

Ozempic has a half-life of 7d against 5d on this page.

Where the number comes from

FDA Trulicity label: terminal half-life ~5 days. How the model works.