Half-life estimate, not bloodwork or dosing advice. Disclaimer.
Weekly GLP-1. Elimination half-life is about 7 days on the Ozempic/Wegovy labels, so weekly doses overlap and climb for roughly 4–5 weeks.
The default row models 0.250 mg as a subcutaneous dose, weekly, for 8 weeks.
Also called Wegovy, Sema, Semaglutide.
| Half-life | 7d |
|---|---|
| Time to peak | 2d |
| Parent hormone | 100% |
| Default dose | 0.250 mg |
| Default frequency | Weekly |
| Default duration | 8 weeks |
On that default row the model counts 8 doses. Steady state is about day 35. Washout runs to about day 37. In the last interval the peak is 0.498 mg and the trough is 0.302 mg, a swing of 39%.
A half-life of 7d means a dose is still present at the next one, so the line climbs and then levels off.
Mounjaro has a half-life of 5d against 7d on this page.
Semaglutide 0.25 → 0.5 plots 0.250 mg weekly for 4 weeks, then 0.500 mg weekly for 4 weeks. It is an illustration already in the app, not a protocol to follow.
FDA Ozempic/Wegovy labels: terminal half-life ~1 week, Tmax 1–3 days. How the model works.