Pedplot

MK-677 plotter

Half-life estimate, not bloodwork or dosing advice. Disclaimer.

t½ 6hTmax 5h100% parentestimate

The prefilled numbers are an example input to draw the curve, not a dose; Pedplot does not suggest one. To step a dose up, add another row of the same compound with a later start day.

Peaks, troughs, and half-life
Not a blood level. The chart shows the estimated milligrams of the drug still in the body, so it will not match a lab result in ng/dL. How the model works. Washout continues after the last dose. Mixed IU and mg protocols are not summed.

Ibutamoren

Peak

26.7 mg

Trough

2.90 mg

Swing

89%

~Steady state

2d

~Washout

1.5d

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MK-677. Oral ghrelin-receptor agonist. No human PK study has been published, so the half-life is an estimate; at daily dosing most of each dose clears before the next. There is no ester, so the line is the dose itself. Also called Ibutamoren, MK 677, Mk677. The half-life is an estimate. Methodology.

Half-life6h
Time to peak5h
Parent hormone100%
Example input25 mg
Example frequencyevery day
Example length8 weeks
Data qualityLow

No primary human PK is published. A review gives 5–6 h (Sinha et al. 2020) and a trial protocol 8 h (NCT05364684); modeled as 6 h. Tmax is an estimate. How the model works.

The example curve

25 mg every day for 8 weeks. With a 6h half-life, it levels off around day 2. The row runs longer than that, so the plateau is on the chart. Between doses it runs from about 2.9 to 26.7 mg, a swing of 89%. Each dose is its own spike. After the last dose, the tail takes about 1.5 days to fall to a few percent.

HGH0.1 days shorter (4h vs 6h).

Sources

  1. Paper. Sinha et al. 2020, Transl Androl Urol, Table 1 (review): ibutamoren oral half-life 5–6 h
  2. Paper. NCT05364684 trial protocol (Mass General Brigham), background: half-life of ibutamoren 8 hours (cited, not measured)
  3. Community estimate. Tmax estimate; no human figure found