Half-life estimate, not bloodwork or dosing advice. Disclaimer.
GLP-1/glucagon dual agonist. Published half-lives vary widely between people, so the value here is an estimate from the middle of that range and is marked as such. There is no ester, so the line is the dose itself. Also called Mazdutide. The half-life is an estimate. Methodology.
| Half-life | 18d |
|---|---|
| Time to peak | 3d |
| Parent hormone | 100% |
| Example input | 3 mg |
| Example frequency | once a week |
| Example length | 8 weeks |
| Data quality | Low |
Ji 2022 range 7.3–44.8 d; 18 d = geometric midpoint, not a reported mean. Median Tmax ~72 h (Ji et al. 2022; Ji et al. 2021). How the model works.
3 mg once a week for 8 weeks. With a 18d half-life, it levels off around day 98. The row ends before that, so the line is still climbing when it stops. Between doses it runs from about 9.23 to 11.2 mg, a swing of 18%. That is fairly flat between doses. After the last dose, the tail takes about 94.3 days to fall to a few percent.