Pedplot

Mounjaro plotter

Half-life estimate, not bloodwork or dosing advice. Disclaimer.

t½ 5dTmax 2d100% parent

The prefilled numbers are an example input to draw the curve, not a dose; Pedplot does not suggest one. To step a dose up, add another row of the same compound with a later start day.

Peaks, troughs, and half-life
Not a blood level. The chart shows the estimated milligrams of the drug still in the body, so it will not match a lab result in ng/dL. How the model works. Washout continues after the last dose. Mixed IU and mg protocols are not summed.

Tirzepatide

Peak

4.02 mg

Trough

2.01 mg

Swing

50%

~Steady state

28d

~Washout

27.5d

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Weekly dual GIP/GLP-1 agonist (Mounjaro / Zepbound). Its half-life is shorter than semaglutide's, so the weekly curve is a bit peakier and clears faster. There is no ester, so the line is the dose itself. Also called Zepbound, Tirz, Tirzepatide.

Half-life5d
Time to peak2d
Parent hormone100%
Example input2.5 mg
Example frequencyonce a week
Example length8 weeks
Data qualityHigh

Mounjaro and Zepbound labels: half-life ~5 days; Tmax 8–72 h (median 24 h on the Zepbound label). How the model works.

The example curve

2.5 mg once a week for 8 weeks. With a 5d half-life, it levels off around day 28. The row runs longer than that, so the plateau is on the chart. Between doses it runs from about 2.01 to 4.02 mg, a swing of 50%. Each dose is its own spike. After the last dose, the tail takes about 27.5 days to fall to a few percent.

Ozempic2 days longer (7d vs 5d).

Sources

  1. FDA label. Mounjaro FDA label, 12.3 Pharmacokinetics: elimination half-life approximately 5 days; Tmax 8 to 72 hours
  2. FDA label. Zepbound FDA label, 12.3 Pharmacokinetics: half-life approximately 5–6 days; median Tmax 24 hours (8 to 72)