Half-life estimate, not bloodwork or dosing advice. Disclaimer.
Weekly dual GIP/GLP-1 agonist. Half-life is about 5 days on the Mounjaro/Zepbound labels, so the weekly curve is a bit peakier than semaglutide and clears faster.
The default row models 2.50 mg as a subcutaneous dose, weekly, for 8 weeks.
Also called Zepbound, Tirz, Tirzepatide.
| Half-life | 5d |
|---|---|
| Time to peak | 2d |
| Parent hormone | 100% |
| Default dose | 2.50 mg |
| Default frequency | Weekly |
| Default duration | 8 weeks |
On that default row the model counts 8 doses. Steady state is about day 25. Washout runs to about day 27. In the last interval the peak is 4.02 mg and the trough is 2.01 mg, a swing of 50%.
A half-life of 5d means a dose is still present at the next one, so the line climbs and then levels off.
Ozempic has a half-life of 7d against 5d on this page.
Tirzepatide 2.5 → 5 plots 2.50 mg weekly for 4 weeks, then 5.00 mg weekly for 4 weeks. It is an illustration already in the app, not a protocol to follow.
FDA Mounjaro/Zepbound labels: terminal half-life ~5 days, Tmax 8–72 hours. How the model works.