Pedplot

Reta plotter

Half-life estimate, not bloodwork or dosing advice. Disclaimer.

t½ 6dTmax 2d100% parent

To step a dose up, add another row of the same compound with a later start day. The chart is remaining active amount, not serum concentration.

Peaks, troughs, and half-life
Estimated remaining active mg. Washout continues after the last dose. Mixed IU and mg protocols are not summed.

Retatrutide

Peak

3.60 mg

Trough

2.02 mg

Swing

44%

~Steady state

30d

~Washout

32d

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How to read this chart

Investigational triple agonist. Published half-life is about 6 days; weekly overlap similar to tirzepatide.

The default row models 2.00 mg as a subcutaneous dose, weekly, for 8 weeks.

Also called Retatrutide.

The numbers

Half-life6d
Time to peak2d
Parent hormone100%
Default dose2.00 mg
Default frequencyWeekly
Default duration8 weeks

What the default curve does

On that default row the model counts 8 doses. Steady state is about day 30. Washout runs to about day 32. In the last interval the peak is 3.60 mg and the trough is 2.02 mg, a swing of 44%.

How often a dose is still there

A half-life of 6d means a dose is still present at the next one, so the line climbs and then levels off.

Closest comparison

Mounjaro has a half-life of 5d against 6d on this page.

Where the number comes from

Phase 2 PK: retatrutide terminal half-life ~6 days. How the model works.