Pedplot

Rybelsus plotter

Half-life estimate, not bloodwork or dosing advice. Disclaimer.

t½ 7dTmax 1d100% parent

To step a dose up, add another row of the same compound with a later start day. The chart is remaining active amount, not serum concentration.

Peaks, troughs, and half-life
Estimated remaining active mg. Washout continues after the last dose. Mixed IU and mg protocols are not summed.

Oral semaglutide

Peak

31.7 mg

Trough

31.7 mg

Swing

0%

~Steady state

35d

~Washout

36d

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How to read this chart

Rybelsus. Same ~7 day half-life as injectable semaglutide but taken daily. The plot is remaining milligrams of the tablet dose, not equivalent exposure to a 2.4 mg injection.

The default row models 3.00 mg as an oral dose, daily (ed), for 8 weeks.

Also called Oral semaglutide.

The numbers

Half-life7d
Time to peak1d
Parent hormone100%
Default dose3.00 mg
Default frequencyDaily (ED)
Default duration8 weeks

What the default curve does

On that default row the model counts 56 doses. Steady state is about day 35. Washout runs to about day 36. In the last interval the peak is 31.7 mg and the trough is 31.7 mg, a swing of 0%.

How often a dose is still there

A half-life of 7d means a dose is still present at the next one, so the line climbs and then levels off.

Closest comparison

Ozempic has a half-life of 7d against 7d on this page.

Where the number comes from

FDA Rybelsus label: half-life ~1 week; daily oral dosing. How the model works.