Half-life estimate, not bloodwork or dosing advice. Disclaimer.
Rybelsus. Same half-life as injectable semaglutide but taken daily. The plot is remaining milligrams of the tablet dose, not the far smaller amount the body absorbs. There is no ester, so the line is the dose itself. Also called Oral semaglutide.
| Half-life | 7d |
|---|---|
| Time to peak | 58m |
| Parent hormone | 100% |
| Example input | 3 mg |
| Example frequency | every day |
| Example length | 8 weeks |
| Data quality | High |
FDA label for Rybelsus and Ozempic tablets: half-life ~1 week; peak ~1 h after the tablet. Bioavailability is 0.4–1% (Rybelsus) and 1–2% (Ozempic tablets); the plot shows tablet milligrams, not absorbed drug. How the model works.
3 mg every day for 8 weeks. With a 7d half-life, it levels off around day 36. The row runs longer than that, so the plateau is on the chart. Between doses it runs from about 28.8 to 31.7 mg, a swing of 9%. That is fairly flat between doses. After the last dose, the tail takes about 35.5 days to fall to a few percent.